Recombinant Human ATG4C Protein (His Tag) | PKSH032100

Recombinant Human ATG4C Protein (His Tag) | PKSH032100 | Gentaur US, UK & Europe Disrtribition

Synonyms: Cysteine Protease ATG4C; AUT-Like 3 Cysteine Endopeptidase; Autophagin-3; Autophagy-Related Cysteine Endopeptidase 3; Autophagy-Related Protein 4 homolog C; ATG4C; APG4C; AUTL1; AUTL3

Active Protein: N/A

Activity: Recombinant Human Autophagy Related 4 Homolog C is produced by our E.coli expression system and the target gene encoding Met1-Leu458 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Autophagy Related 4 Homolog C is produced by our E.coli expression system and the target gene encoding Met1-Leu458 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 53.6 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 10% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Background: Cysteine Protease ATG4C (ATG4C) belongs to the peptidase C54 family. It is required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form which is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ATG4C is a cytoplasmic protein and high expressed in skeletal muscle, liver, testis and heart. ATG4C can be inhibited by N-ethylmaleimide.

Research Area: Signal Transduction, Cell biology, Cardiovascular, Cancer, metabolism,