Recombinant Human APOM Protein (Fc Tag) | PKSH030622

Recombinant Human APOM Protein (Fc Tag) | PKSH030622 | Gentaur US, UK & Europe Disrtribition

Synonyms: Apolipoprotein M; Apo-M; ApoM; Protein G3a; APOM; G3A; NG20

Active Protein: N/A

Activity: A DNA sequence encoding the human APOM (O95445) (Met 1-Asn 188) was fused with the Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the human APOM (O95445) (Met 1-Asn 188) was fused with the Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-Fc

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 45.6 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: ApoM (apolipoprotein M) is an apolipoprotein and member of the lipocalin protein family. The lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They have an eight-stranded; antiparallel; symmetrical _-barrel fold; which is in essence a beta sheet which has been rolled into a cylindrical shape. Inside this barrel is located a ligand binding site. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. Lipocalins have been associated with many biological processes; among them immune response; pheromone transport; biological prostaglandin synthesis; retinoid binding; and cancer cell interactions. Lipocalins are comparatively small in size; and are thus less complicated to study as opposed to large; bulky proteins. They can also bind to various ligands for different biological purposes. ApoM is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. ApoM is involved in lipid transport and can bind sphingosine-1-phosphate; myristic acid; palmitic acid and stearic acid; retinol; all-trans-retinoic acid and 9-cis-retinoic acid.

Research Area: Signal Transduction, Cardiovascular, Cancer, metabolism,