Recombinant Human Apolipoprotein A-I/ApoAI Protein (His Tag) | PKSH031486

Recombinant Human Apolipoprotein A-I/ApoAI Protein (His Tag) | PKSH031486 | Gentaur US, UK & Europe Disrtribition

Synonyms: Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1; APOA1

Active Protein: N/A

Activity: A DNA sequence encoding the mature form of human APOA1 (P02647) (Asp25-Gln267) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the mature form of human APOA1 (P02647) (Asp25-Gln267) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 30.7 kDa

Formulation: Lyophilized from sterile PBS, 10% Glycerol, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and circulatory system. APOA1 is the main component of high density lipoprotein (HDL) in plasma and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters; and thus play a major role in cholesterol efflux from peripheral cells. As a major component of the HDL complex; APOA1 helps to clear cholesterol from arteries. APOA1 is also characterized as a prostacyclin stabilizing factor; and thus may have an anticlotting effect. Defects in encoding gene may result in HDL deficiencies; including Tangier disease; and with systemic non-neuropathic amyloidosis. Men carrying a mutation may develop premature coronary artery disease.

Research Area: Signal Transduction, Cardiovascular, Neuroscience, Cancer, metabolism,