Recombinant Human ANGPTL8/β-trophin Protein (Fc Tag) | PKSH032067

Recombinant Human ANGPTL8/β-trophin Protein (Fc Tag) | PKSH032067 | Gentaur US, UK & Europe Disrtribition

Synonyms: Betatrophin;Angiopoietin-like protein 8;Lipasin;Angptl8

Active Protein: N/A

Activity: Recombinant Human Angiopoietin-like protein 8 is produced by our Mammalian expression system and the target gene encoding Ala22-Ala198 is expressed with a Fc tag at the N-terminus.

Protein Construction: Recombinant Human Angiopoietin-like protein 8 is produced by our Mammalian expression system and the target gene encoding Ala22-Ala198 is expressed with a Fc tag at the N-terminus.

Fusion Tag: N-Fc

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 46.0 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

Research Area: Cell biology