Recombinant Human AKR1C3 Protein (His Tag) | PKSH032055

Recombinant Human AKR1C3 Protein (His Tag) | PKSH032055 | Gentaur US, UK & Europe Disrtribition

Synonyms: Aldo-Keto Reductase Family 1 Member C3; 17-Beta-Hydroxysteroid Dehydrogenase Type 5; 17-Beta-HSD 5; 3-Alpha-HSD Type II Brain; 3-Alpha-Hydroxysteroid Dehydrogenase Type 2; 3-Alpha-HSD Type 2; Chlordecone Reductase Homolog HAKRb; Dihydrodiol Dehydrogenase 3; DD-3; DD3; Dihydrodiol Dehydrogenase Type I; HA1753; Indanol Dehydrogenase; Prostaglandin F Synthase; Testosterone 17-Beta-Dehydrogenase 5; Trans-1;2-Dihydrobenzene-1;2-Diol Dehydrogenase; AKR1C3; DDH1; HSD17B5; KIAA0119; PGFS

Active Protein: N/A

Activity: Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 37.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha, 11-beta-PGF2 to PGD2, which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

Research Area: Signal Transduction, Neuroscience, Cancer, metabolism,