Recombinant Human AgRP/AGRP Protein (His Tag) | PKSH031894

Recombinant Human AgRP/AGRP Protein (His Tag) | PKSH031894 | Gentaur US, UK & Europe Disrtribition

Synonyms: AGRT;ART;ASIP2

Active Protein: N/A

Activity: A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed, with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed, with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 14 kDa

Formulation: Lyophilized from sterile PBS, pH 7.2

Reconstitution: Please refer to the printed manual for detailed information.

Background: Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

Research Area: Signal Transduction, Cardiovascular, Neuroscience, Cancer, metabolism,