Description
Recombinant Human Activin Receptor 2B/ACVR2B Protein (Fc & His Tag)(Active) | PKSH032041 | Gentaur US, UK & Europe Disrtribition
Synonyms: Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B;Bone Morphogenetic Protein Receptor Type-2; BMP Type-2 Receptor; BMPR-3; Bone Morphogenetic Protein Receptor Type II; BMP Type II Receptor
Active Protein: Active protein
Activity: Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc; 6His tag at the C-terminus.
Protein Construction: Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc; 6His tag at the C-terminus.
Fusion Tag: C-Fc-6His
Species: Human
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per µg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 41.3 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.
Research Area: Signal Transduction, Stem cells
