Recombinant Human ACADM/MCAD Protein (His Tag) | PKSH032032

Recombinant Human ACADM/MCAD Protein (His Tag) | PKSH032032 | Gentaur US, UK & Europe Disrtribition

Synonyms: Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochondrial; MCAD; ACADM

Active Protein: N/A

Activity: Recombinant Human Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial is produced by our E.coli expression system and the target gene encoding Lys26-Asn421 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Human Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial is produced by our E.coli expression system and the target gene encoding Lys26-Asn421 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 45.9 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 0.1M NaCl, 20% Glycerol, pH 8.5.

Reconstitution: Not Applicable

Background: Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death.

Research Area: Signal Transduction, Cardiovascular, Cancer, metabolism,