Description
Recombinant Cynomolgus TIM-3/HAVCR2 Protein (His Tag) | PKSQ050023 | Gentaur US, UK & Europe Disrtribition
Synonyms: T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3
Active Protein: N/A
Activity: Recombinant Cynomolgus TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus.
Protein Construction: Recombinant Cynomolgus TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus.
Fusion Tag: N-His
Species: Cynomolgus
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 20.8 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Research Area: N/A
