Description
Recombinant Cynomolgus FcRn/FCGRT & B2M Heterodimer Protein (Flag & His Tag) | PKSQ050037 | Gentaur US, UK & Europe Disrtribition
Synonyms: Beta-2-Microglobulin; B2M
Active Protein: N/A
Activity: Recombinant Cynomolgus FCGRT & B2M Heterodimer is produced by our Mammalian expression system and the target gene encoding Ile21-Met119&Ala24-Ser297 is expressedwith a Flag tag at the C-terminus, 6His tag at the C-terminus.
Protein Construction: Recombinant Cynomolgus FCGRT & B2M Heterodimer is produced by our Mammalian expression system and the target gene encoding Ile21-Met119&Ala24-Ser297 is expressedwith a Flag tag at the C-terminus, 6His tag at the C-terminus.
Fusion Tag: C-Flag, C-His
Species: Cynomolgus
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 12.6&31.3 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
Research Area: N/A
