Description
Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag) | PKSQ050044 | Gentaur US, UK & Europe Disrtribition
Synonyms: Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5
Active Protein: N/A
Activity: Recombinant Cynomolgus CD40 is produced by our Mammalian expression system and the target gene encoding Glu21-Arg193 is expressed with a Fc tag at the C-terminus.
Protein Construction: Recombinant Cynomolgus CD40 is produced by our Mammalian expression system and the target gene encoding Glu21-Arg193 is expressed with a Fc tag at the C-terminus.
Fusion Tag: C-Fc
Species: Cynomolgus
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 90 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 46.3 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
Reconstitution: Please refer to the printed manual for detailed information.
Background: CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.
Research Area: N/A
