Description
Rat PSMA / FOLH1 Protein, His Tag (active enzyme, MALS verified) | PSA-R5245-1mg| Gentaur Distribution US, UK & Europe
Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly – gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N – acetylated – alpha – linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Source: Rat PSMA, His Tag (PSA-R5245) is expressed from human 293 cells (HEK293). It contains AA Lys 45 - Asp 752 (Accession # P70627-1).
Format: Liquid.
Tag: N-10×His.
Expression System: HEK293.
Expression Region: Lys 45 - Asp 752.
Conjugate: Unconjugated.
Molecular Weight: 81.4 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 81.4 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 25 mM MES, 500 mM NaCl, pH6.5.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
