Description
Rat Nectin-4 Protein, Fc Tag (MALS verified) | NE4-R5255-1mg| Gentaur Distribution US, UK & Europe
Nectin-4 (Nectin cell adhesion molecule 4) is a Nectin and nectin-like family of cell adhesion molecules. It is found in high levels in normal embryonic and fetal tissues, but decreases after adulthood and is limited in distribution in healthy tissues. Nectin-4 is overexpressed in a variety of tumor cells and promotes tumor cell growth and proliferation. Solid tumors with high expression of Nectin-4 include bladder cancer, pancreatic cancer, triple negative breast cancer, non-small cell lung cancer, stomach cancer, esophageal cancer, ovarian cancer and many other cancers. Studies have found that Nectin-4 promotes tumor cell proliferation, differentiation, migration and invasion by activating the PI3K/Akt pathway, and is believed to play an important role in the occurrence and metastasis of cancer. It is based on these research backgrounds that drug research targeting this target has emerged.
Source: Rat Nectin-4, Fc Tag (NE4-R5255) is expressed from human 293 cells (HEK293). It contains AA Tyr 28 - Val 348 (Accession # D3ZET1-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Tyr 28 - Val 348.
Conjugate: Unconjugated.
Molecular Weight: 61.1 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 61.1 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
