Rat B7-H2 / ICOSLG Protein, Fc Tag | B72-R5259-100ug

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SKU:
716-B72-R5259-100ug
Availability:
IN STOCK
Weight:
1.20 KGS
€460.00
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Description

Rat B7-H2 / ICOSLG Protein, Fc Tag | B72-R5259-100ug| Gentaur Distribution US, UK & Europe

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Source: Rat B7-H2, Fc Tag (B72-R5259) is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Lys 261 (Accession # XP_006256322.1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Glu 25 - Lys 261.

Conjugate: Unconjugated.

Molecular Weight: 53.4 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.4 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT

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Additional Information

Size:
100 ug
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