Description
RARα Reporter - HEK293 Recombinant Cell Line | 60503 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Cell Line
Application: The RARα Reporter (Luc)-HEK293 Cell Line is designed for monitoring the activity of retinoic acid receptor alpha (RARα).
• Monitor RARα-regulated pathway activity
• Screen agonists or antagonists of RARα.
Background: RAR belongs to a family of nuclear receptors and has three subtypes, RARα, RARβ, and RARγ. RAR heterodimerizes with RXR (retinoid X receptor) and acts as a transcription factor that regulates the growth and differentiation of both normal and malignant cells. When RAR binds to its ligands, all-trans retinoic acid or 9-cis retinoic acid, RAR/RXR heterodimer binds to retinoic acid response elements in the promoter region of target genes and recruits coactivator proteins, leading to transcription and expression of the downstream target genes.
Description: The RARα Reporter (Luc)-HEK293 Cell Line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARα (NM_000964).
Product Type: Cell Line
Shippement Condition: -80°C
