Description
Raf1 Antibody / c-Raf | F54952-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: FACS, IF, IHC-P, WB
Buffer: N/A
Limitation: This RAF1 antibody is available for research use only.
Purity: Antigen affinity purified
Description: RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for the RAF1 antibody.
Storage: Aliquot the RAF1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
