Pyruvate Kinase Antibody / PKM2 | F54017-0.1ML

Pyruvate Kinase Antibody / PKM2 | F54017-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

Format: Purified

Clone: 1A7-G6-H6

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse, Rat, Primate

Application: WB, ICC/IF

Buffer: N/A

Limitation: This PKM2 antibody is available for research use only.

Purity: Protein G affinity

Description: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]

Immunogen: A human recombinant partial protein was used as the immunogen for this PKM2 antibody.

Storage: Store the PKM2 antibody at -20 °C.