Description
Pyruvate Kinase Antibody / PKM2 | F40140-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Primate, Rat
Application: WB, IF, IHC, ELISA
Buffer: N/A
Limitation: This PKM2 antibody is available for research use only.
Purity: Purified
Description: PKM2 is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]
Immunogen: A portion of amino acids 476-505 from the human protein was used as the immunogen for this PKM2 antibody.
Storage: Aliquot the PKM2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
