Pyruvate Dehydrogenase E2 Antibody / DLAT | F54820-0.4ML

Pyruvate Dehydrogenase E2 Antibody / DLAT | F54820-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: FACS, IHC-P, WB

Buffer: N/A

Limitation: This Pyruvate Dehydrogenase E2 antibody is available for research use only.

Purity: Antigen affinity purified

Description: DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

Immunogen: A portion of amino acids 579-607 from the human protein was used as the immunogen for the Pyruvate Dehydrogenase E2 antibody.

Storage: Aliquot the Pyruvate Dehydrogenase E2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.