Description
Purified Anti-Mouse CD279/PD-1 Antibody | DL21638F-1 | Gentaur US, UK & Europe Disrtribition
Synonyms: PD-1, Programmed Death-1
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Concentration: 0.5 mg/mL
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Isotype: Rat IgG2a, κ
Storage: Store at 2~8°C. Do not freeze.
