Description
Purified Anti-Mouse CD272 Antibody | DL20410F-1 | Gentaur US, UK & Europe Disrtribition
Synonyms: B- and T-lymphocyte attenuator,Btla,B- and T-lymphocyte-associated protein,CD272,Btla
Reactivity: Mouse
Host: Rat
Application: FCM
Background: CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and nave T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
Concentration: 0.5 mg/mL
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Isotype: Rat IgG1, κ
Storage: Store at 2~8°C. Do not freeze.
