Description
Purified Anti-Human CD274/PD-L1 Antibody | DL21664F-2 | Gentaur US, UK & Europe Disrtribition
Synonyms: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Reactivity: Human
Host: Mouse
Application: FCM
Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1) . This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Concentration: 0.5 mg/mL
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Isotype: Mouse IgG2b, κ
Storage: Store at 2~8°C. Do not freeze.
