Description
Puma Antibody | F42785-0.4ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, IF, FACS, ELISA
Buffer: N/A
Limitation: This Puma antibody is available for research use only.
Purity: Purified
Description: PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Immunogen: A portion of amino acids 119-154 (BH3 domain) from the human protein was used as the immunogen for this Puma antibody.
Storage: Aliquot the Puma antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
