PU.1 Antibody / SPI1 | V8999-100UG

PU.1 Antibody / SPI1 | V8999-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: PU1/2118

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This PU.1 antibody is available for research use only.

Purity: Protein A/G affinity

Description: PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.

Immunogen: A portion of amino acids 16-170 was used as the immunogen for the PU.1 antibody.

Storage: Aliquot the PU.1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.