PTP1B(1-321)/PTPN1, GST-tag | 30010

PTP1B(1-321)/PTPN1, GST-tag | 30010 | Gentaur US, UK & Europe Disrtribition

Category: Protein Phosphatase/Non-Receptor

Application: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.

Background: Protein tyrosine phosphatase nonreceptor, type 1 (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family. PTPN1 catalyze the hydrolysis of the phosphate monoesters specifically from tyrosine residues. PTPN1 is known to be involved in signaling pathways that regulate a variety of cellular processes including cell growth and oncogenic transformation. PTPN1 also has been shown to act as a negative regulator of insulin signaling. PTPN1 has also been reported to dephosphorylate epidermal growth factor receptor kinase, which implicated the role of this phosphatase in cell growth control and cell response to interferon stimulation.

Description: Human PTP1B protein tyrosine phosphatase, also known as PTPN1 (GenBank accession no. M31724), a.a. 1-321 (catalytic domain), with N-terminal GST-tag, MW=63.3 kDa, expressed in E. coli.

Product Type: Protein

Shippement Condition: -80°C