Description
PTCH2 Antibody (Patched 2) | R30958 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse
Application: WB
Buffer: N/A
Limitation: This PTCH2 antibody is available for research use only.
Purity: Antigen affinity
Description: PTCH2 (Patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for PTCH2 in adult epidermal homeostasis via Shh signaling.
Immunogen: An amino acid sequence from the C-terminus of human Patched 2 (WLHDKYDTTGENLRIPP) was used as the immunogen for this PTCH2 antibody.
Storage: After reconstitution, the PTCH2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
