Description
PSD-95 Antibody (PSD95) | R31419 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P, IF
Buffer: Lyophilized from 1X PBS with 2% Trehalose
Limitation: This PSD-95 antibody is available for research use only.
Purity: Antigen affinity
Description: DLG4 (Discs large homolog 4), also known as Post-synaptic density protein 95 (PSD-95) or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.
Immunogen: An amino acid sequence from the C-terminus of human PSD-95 (RRVERREWSRLKAKDW) was used as the immunogen for this PSD-95 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the PSD-95 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
