PROX1 Antibody | F47894-0.4ML

PROX1 Antibody | F47894-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Rat

Application: WB, IF, ELISA

Buffer: N/A

Limitation: This PROX1 antibody is available for research use only.

Purity: Purified

Description: The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.

Immunogen: A portion of amino acids 492-522 from the human protein was used as the immunogen for this PROX1 antibody.

Storage: Aliquot the PROX1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.