Protocadherin alpha-C2 Antibody / PCDHAC2 | F54638-0.4ML

Protocadherin alpha-C2 Antibody / PCDHAC2 | F54638-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: FACS, IF, IHC-P, WB

Buffer: N/A

Limitation: This Protocadherin alpha-C2 antibody is available for research use only.

Purity: Antigen affinity purified

Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Immunogen: A portion of amino acids 616-644 from the human protein was used as the immunogen for the Protocadherin alpha-C2 antibody.

Storage: Aliquot the Protocadherin alpha-C2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.