Description
PROTAC Optimization Kit for CDK Kinase-Cereblon Binding | 79924 | Gentaur US, UK & Europe Disrtribition
Category: PROTACS/Assay Kit
Application: Great for identifying and optimizing PROTACs targeting the CDK family of kinases, the design of novel molecules targeting CRBN, and comparison of activities of different PROTACs.
Background: N/A
Description: The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
Product Type: Assay Kit
Shippement Condition: -80°C
