Description
Proprotein Convertase 1/3 Antibody | R31196 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC-P, IF
Buffer: N/A
Limitation: This Proprotein Convertase 1/3 antibody is available for research use only.
Purity: Antigen affinity
Description: Proprotein Convertase, Subtilisin/Kexin-Type, 1, also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. It is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al.(1991) mapped the gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al.(1996) noted that PCSK1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PCSK1 mutations, Jackson et al.(2003) concluded that human intestinal absorptive function is dependent on the enzymes activity.
Immunogen: An amino acid sequence from the C-terminus of human Proprotein Convertase 1/3 (DVFYNTKPYKHRDDR) was used as the immunogen for this Proprotein Convertase 1/3 antibody (100% homologous in human, mouse and rat).
Storage: After reconstitution, the Proprotein Convertase 1/3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
