Description
PRMT7, FLAG-tag | 51054 | Gentaur US, UK & Europe Disrtribition
Category: Methyltransferase/Enzymes
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer
Description: Human PRMT7 (protein arginine methyltransferase 7), GenBank Accession No. NM_019023, a.a. 2-692(end) with N-terminal FLAG-tag, MW=80 kDa, expressed in Sf9 cells using a Baculovirus expression system.
Product Type: Protein
Shippement Condition: -80°C
