PRMT6 (HRMT1L6), His-tag | 51049

PRMT6 (HRMT1L6), His-tag | 51049 | Gentaur US, UK & Europe Disrtribition

Category: Methyltransferase/Enzymes

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: Arginine methyltransferase that can both catalyze the formation of monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 Arg-2 to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 Lys-4 (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 Arg-3 (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

Description: Human PRMT6 (GenBank Accession No. NM_018137), a.a. 2-375(end), with N-terminal His-tag, MW=43 kDa, expressed in E. coli.

Product Type: Protein

Shippement Condition: -80°C