PRMT3, GST-tag | 51043

PRMT3, GST-tag | 51043 | Gentaur US, UK & Europe Disrtribition

Category: Methyltransferase/Enzymes

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: PRMT3 is a protein arginine methyltransferase that catalyze the formation of asymmetric N(G),N(G)-dimethylarginine (ADMA) residues in proteins. 40S ribosomal protein S2 is a physiological substrate of PRMT3 and PRMT3 regulates ribosome biosynthesis at a stage beyond pre-rRNA processing. DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene that can significantly inhibits PRMT3 methylation of cellular substrates. Modulation of post-translational methylation may be an important mechanism through which DAL-1/4.1B affects tumor cell growth.

Description: Human PRMT3 (GenBank Accession No. NM_005788), a.a. 2-end, with N-terminal GST-tag, MW=86 kDa, expressed in an E. coli expression system.

Product Type: Protein

Shippement Condition: -80°C