PRC1 Antibody | RQ4746

PRC1 Antibody | RQ4746 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: EH-16

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This PRC1 antibody is available for research use only.

Purity: Affinity purified

Description: Protein regulator of cytokinesis 1 (PRC1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. [UniProt]

Immunogen: A synthetic peptide specific to human PRC1 was used as the immunogen for the PRC1 antibody.

Storage: Store the PRC1 antibody at -20 °C.