Description
PML Antibody | F48066-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, IF, FACS, ELISA
Buffer: N/A
Limitation: This PML antibody is available for research use only.
Purity: Antigen affinity
Description: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).
Immunogen: A portion of amino acids 470-499 (sumoylation site) from the human protein was used as the immunogen for this PML antibody.
Storage: Aliquot the PML antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
