PKC ι/λ, GST-tag | 40015

PKC ι/λ, GST-tag | 40015 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: PKCι (PKC iota) is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCζ (PCKzeta), with 72% identity overall rising to 84% in the catalytic domain. Protein kinase Cι (PKCiota) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis.

Description: Human PKC iota (PCKι), also known as PKClambda (PKCλ), GenBank Accession No. NM_002740, a.a. 2-587 with N-terminal GST-tag, expressed in a Baculovirus infected Sf9 cell expression system. MW= 93 kDa.

Product Type: Protein

Shippement Condition: -80°C