Description
PINK1 Antibody | F53741-0.1ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In ascites with 0.09% sodium azide
Format: Ascites
Clone: 38CT20.8.5
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse
Application: WB, IHC, ELISA
Buffer: N/A
Limitation: This PINK1 antibody is available for research use only.
Purity: Ascites
Description: PINK1 protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form. [UniProt]
Immunogen: Recombinant protein was used to produced this PINK1 antibody.
Storage: Aliquot the PINK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
