PIM1, Active, GST-tag | 41107

PIM1, Active, GST-tag | 41107 | Gentaur US, UK & Europe Disrtribition

Category: Kinase-Serine/Threonine/Protein

Application: Useful for studying enzyme kinetics, screening inhibitors, and selectivity profiling.

Background: PIM1 is a proto-oncogene that belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, PIM1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others (1). Expression of PIM1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational (2). Expression of PIM1 is mediated through activation of the JAK/STAT pathway.

Description: Recombinant human serine/threonine-protein kinase PIM1 (PIM1), GenBank Accession No. NM_002648, full-length with an N-terminal GST tag and expressed in a baculovirus infected Sf9 insect cell expression system. MW = 62 kDa.

Product Type: Protein

Shippement Condition: Dry ice