Description
Phospholipase A2 Antibody / PLA2G4A / cPLA2 | F54970-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, FACS, IF, IHC-P
Buffer: N/A
Limitation: This Phospholipase A2 antibody is available for research use only.
Purity: Antigen affinity purified
Description: PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Immunogen: A portion of amino acids 513-541 from the human protein was used as the immunogen for the Phospholipase A2 antibody.
Storage: Aliquot the Phospholipase A2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
