Description
Phospho-P53 (Ser46) Polyclonal Antibody | E-AB-20955 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Monkey
Host: Rabbit
Isotype: IgG
Application: WB, ELISA
Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthesized peptide derived from human p53 around the phosphorylation site of Ser46
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Dilution: WB 1:500-1:2000, ELISA 1:5000
Conjugation: Unconjugated
Calculated Molecular Weight: 44 kDa
Observed Molecular Weight: 44 kDa
Clonality: Polyclonal
