Phospho-EIF2S1 Antibody (pS51) | RQ5120

Phospho-EIF2S1 Antibody (pS51) | RQ5120 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: IO-5

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human

Application: IHC-P, WB

Buffer: N/A

Limitation: This phospho-EIF2S1 antibody (pS51) is available for research use only.

Purity: Affinity purified

Description: EIF2S1 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. [UniProt]

Immunogen: A synthetic peptide specific to human EIF2S1 (surrounding phosphorylated S51) was used as the immunogen for the phospho-EIF2S1 antibody.

Storage: Store the phospho-EIF2S1 antibody (pS51) at -20 °C.