Description
PEST (PTPN12), GST-tag | 30023 | Gentaur US, UK & Europe Disrtribition
Category: Protein Phosphatase/Non-Receptor
Application: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.
Background: Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.
Description: Human recombinant PTP-PEST, also known as PTPN12 (GenBank Accession #NM_002835), a.a. 2-300 (catalytic domain) with N-terminal GST tag, MW=61.4 kDa, expressed in an E. coli expression system.
Product Type: Protein
Shippement Condition: -80°C
