Description
Perlecan Antibody (Large) | V2601-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Format: Purified
Clone: SPM255
Host Animal: Rat
Clonality: Monoclonal (rat origin)
Species Reactivity: Human
Application: IHC-P
Buffer: N/A
Limitation: This anti-Perlecan antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Immunogen: A murine EHS laminin preparation was used as the immunogen for the anti-Perlecan antibody.
Storage: Store the anti-Perlecan antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
