Perlecan Antibody (Large) | V2601-100UG

Perlecan Antibody (Large) | V2601-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: SPM255

Host Animal: Rat

Clonality: Monoclonal (rat origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This anti-Perlecan antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Immunogen: A murine EHS laminin preparation was used as the immunogen for the anti-Perlecan antibody.

Storage: Store the anti-Perlecan antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).