Description
PE-Labeled Human PD-1 / PDCD1 Protein, Fc, His Tag (recommended for neutralizing assay) | PD1-HP2F2-50tests| Gentaur Distribution US, UK & Europe
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
Source: PE-Labeled Human PD-1, Fc, His Tag (Cat. No. PD1-HP2F2) is produced via site-specific conjugation of PE to Human PD-1, Fc, His Tag under optimal conditions with a proprietary technology. Human PD-1, Fc, His Tag is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # Q15116-1).
Format: Powder.
Tag: C-Fc & C-6×His.
Expression System: HEK293.
Expression Region: Leu 25 - Gln 167.
Conjugate: PE Labeled.
Molecular Weight: 44.7 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 44.7 kDa.
Purity: N/A.
Buffer: PBS, 0.5% BSA, pH7.4.
Storage Conditions: -20℃, aviod light.
Shipping Conditions: RT
