Description
PE Anti-Human CD274/PD-L1 Antibody | DL21667F-3 | Gentaur US, UK & Europe Disrtribition
Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Reactivity: Human
Host: Mouse
Application: FCM
Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1) . This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Concentration: N/A
Conjugation: PE
Buffer: PBS with 0.05% Proclin300, 1% BSA
Isotype: Mouse IgG2b, κ
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
