PDX1 Antibody | F47892-0.08ML

PDX1 Antibody | F47892-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IF, WB, IHC, ELISA

Buffer: N/A

Limitation: This PDX1 antibody is available for research use only.

Purity: Antigen affinity

Description: PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this PDX1 antibody.

Storage: Aliquot the PDX1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.