Description
PDCD1 Antibody / PD-1 / PD1 | V8347-20UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: RMP1-14
Host Animal: Rat
Clonality: Monoclonal (rat origin)
Species Reactivity: Mouse
Application: ELISA, Neutralization, FACS, IF
Buffer: N/A
Limitation: This PD1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).
Immunogen: PDCD1 transfected BHK cells were used as the immunogen for the PD1 antibody.
Storage: Store the PD1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
