PD-L2 Antibody / Programmed death ligand 2 / CD273 | V8176-100UG

PD-L2 Antibody / Programmed death ligand 2 / CD273 | V8176-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: PDL2/1850

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS

Buffer: N/A

Limitation: This PDL2 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Immunogen: A recombinant fragment of human PD-L2 protein within amino acids 27-220 was used as the immunogen for the PDL2 antibody.

Storage: Store the PDL2 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).